Sweet and Sickly

Everything in moderation, including moderation. That’s Wilde … but did he really mean everything, including sugar, or was Oscar teasing us? What would he say since we consume immoderate amounts of the sweet stuff? And does it matter anyway?

granulated sugar

Sugar for a man-year

Some twenty years ago, I asked my students in Edinburgh to keep a food diary for their physiology class. Two weeks later they calculated their daily average rations of protein, fat, carbs, and micronutrients. Some of the young men consumed half of their carbs as sugar—equivalent to a 3 lb bag (1.4 kg) every week—mainly in candies, cakes, sodas, juices, bread, processed foods, and, of course, ad libitum volumes of beer. At that rate they swallowed four tons of refined sugar in a lifetime, contributing over 20 % to their total calories. The women consumed rather less of everything, but some were nonetheless so shocked that they abruptly changed their food choices, and sugar was first for the axe.

Scotland has been the land of “bread and buns” since Greenock became a Sugaropolis on the River Clyde. Ships docking after plying the Atlantic trade route from the West Indies provided a bustling trade that made sugar cheap enough for everyone to afford to excess. You can find it added to most things on your pantry and fridge shelves—from apple juice to zucchini in cans—often unnecessarily or excessive. Sugar consumption boomed throughout much of the Western World, and there was hardly ever a whimper of reproach.

Why would anyone protest? Isn’t a sweet gift a token of love? Parents, friends, and guests would buy candies, chocolate, ice cream, and candy floss (“candy cotton”) for us children, and more recently (if only in Scotland), deep fried Mars bars with a whopping 1,000 sweet, greasy calories. We were told that candy was good because it “gave us energy” (as if we were not hyperkinetic enough), and no one accused the gift-bearer of harming children. It was good for school dentists too, who labored like road workers inside our gaping mouths with jackhammers and caterpillar excavators. Ever since Queen Elizabeth I smiled a row of blackened stumps, “British teeth” have been synonymous with crumbling ruins for North American dentists.

Raw Mars bar before deep frying

Raw Mars bar before deep frying

Apart from the black mark of caries, ‘sweetness’ has resonated in our language for centuries with everything wholesome and beautiful— a sweet girl/ boy/ spirit/ victory/ life/ air/ scent/ friendship.  And Hamlet’s mother in her adieu, “Sweet to the sweet, farewell.”

Sweetness and sugar are interchangeable and both sound positive in almost every way, including financially. Sugar futures are safe bets for investors because the commodity reaches multiple markets—food, drink, fuel. And when Great Grandpa Francis took a retirement job as chairman of the International Sugar Council he was in a sweet spot. Harrowing memories of slave labor had faded, and there were none of the modern worries about environmental and nutritional impacts.

Neither did our doctors ever condemn a sweet tooth, as far as I can remember. However, unknown to us and yet not far from home there was a maverick fighting a single-handed battle against sugar interests.

John Yudkin

A book pulled from the dustbin

John Yudkin (1910- 1995), a London professor of physiology, published Pure, White and Deadly in 1972 (Sweet and Dangerous in the USA). The title reads like an Agatha Christie arsenic plot, but his book claimed that sugar is a slow poison, and that did not endear him to his profession or the industry. They strenuously barred him from guest lectureships and expert panels, although with typical British understatement, he wrote that, “relations with one or two friends in industry have occasionally become rather strained.” He also had the rare distinction of his book being condemned even before it was published: “(this book) is science fiction … and for your dustbin” (The World Sugar Research Organization).  The criticism must have pained him, because he was a “jolly man” according to one of my colleagues.

If World Sugar represented the bitter enemy in industry, Ancel Keys at the University of Minnesota was his bête noire in academia (blogpost December 21, 2014). After President Dwight Eisenhower suffered a series of heart attacks in 1955, American epidemiologists focused on the growing epidemic of heart disease, and Dr. Keys led the campaign against saturated dietary fat and for lowering blood cholesterol. Keys made the front cover of Time magazine and leaves a legacy of official dietary advice and food choices in our supermarkets.

Yudkin was a rare critic of Keys’ famous Seven Countries study of health and diet, and much else that claimed to prove a case against animal fat. He argued that the choice of countries was arbitrary, and sometimes the link with disease and obesity was stronger with sugar than fat. Moreover, the Canadian Inuit and African Masai subsisted on high fat diets (>50% of calories) consisting of meat, blood, blubber, and milk without developing heart disease, or at least until they adopted a Western diet. It was a similar story for Sephardic Jews before and after migration from Yemen to Israel. And the acclaimed Mediterranean diet, which is poor in ‘bad fats’ and rich in ‘good’ ones, happens to be low in sugar.

Rather accusingly, he said the low fat bandwagon was based on the elementary error of assuming that a correlation proves causation, and after it started rolling it was propelled by vested interests. As far as I know, he never met its architect, Ancel Keys, which was probably merciful because they might have come to blows, verbally if not worse. The bitterness went deeper than an esoteric tiff between academics because Keys had brought round his government, much of the medical profession, and the food industry to his cause. If he was wrong, there was blood on his hands—bad dietary advice to the nation would fail to roll back the tide of heart disease, and this has not happened after fifty years. As if to rub salt in a wound, Yudkin showed the correlation with disease is better for TV ownership, which is not as ironic as first sight. Heart disease is associated with all the hallmarks of affluence—sedentary lifestyle, obesity, smoking, fatty and sugary diets. The story is complex.

Perhaps he deliberately exaggerated as prophets are wont to do. He had to struggle to get attention from a profession and authorities who had turned their backs on him. Not only did he single out sugar as a chief cause of the triad of heart disease, obesity, and adult-type diabetes, but claimed it might be responsible for a mixed bag of gout, diverticulitis, dermatitis, duodenal ulcers, vision problems, and even cancer. In claiming sugar was the bogeyman of so many ailments he gave opponents a better chance to ridicule him. He wasn’t taken seriously until after his death, when another outsider stepped forward to carry the baton.

Gary Taubes in a New York Times magazine article (July, 2002) asked, What if fat doesn’t make you fat? Like his predecessor, he thought the triad was more likely caused by hormonal changes.

When glucose is absorbed into the bloodstream it stimulates insulin secretion from the pancreas. Insulin keeps glucose in check by a ‘handshake’ with a receptor on cells that opens a gate for glucose to enter where it is burnt for energy or stored as fats, to excess if sugar and insulin remain high. How the metabolic balancing act leads to a spectrum of disease is still being worked out, but its disorders seem to be related to the aging process. While studying worms in her lab at the University of California, Cynthia Kenyon found that insulin-like genes switched on by a sugary diet shorten their lifespan. After her discovery, she switched to a low glycemic diet.

Mother’s rule at the meal table was wiser than she knew. My brothers and I regarded the savory course as something to struggle through before we were rewarded with a sweet dessert. We were never allowed to reverse the order. The protein and fat lying heavy in our stomachs when the sugar came down the chute delayed gastric emptying, slowing its path into the small intestine for absorption and curbing a rush of glucose into the blood. Likewise, she forbad candy between meals, which avoids an unnecessary glucose spike, although her rationale was to dodge the dentist.

Yudkin also admitted struggling with a sweet tooth when young and an expanding waistline in mid-life. He slimmed by switching to a low-carb diet, which was a long time before we heard about the Atkins diet. But he wasn’t the pioneer of low carbs; that credit belongs to a Victorian Londoner, who, as a coffin-maker, knew something about corpulence. William Banting (1796-1878) found a low-carb diet helped him to slim, and he broadcast his discovery in a book that sold well, if not in medical circles. By an odd twist of history, one of his descendants won the Nobel Prize in 1923 for the discovery of insulin. Banting’s formula was close to the modern paleo diet, which I will return to in another blogpost.

Yudkin might chuckle now that sugar is portrayed as the new tobacco. You know the climate of science has changed when America’s First Lady and Dr. Oz have taken theories on board, even if the originator is forgotten.

But how could so many experts be so wrong for so long? Science is the most objective path to knowledge, but still a human endeavor. When a complicated case is heard in the court of science the judgment depends not only on the evidence presented but on the outcome of a clash between the prosecutor and defending attorney. Ancel Keys would have made a very persuasive trial lawyer and, more importantly, nutritional science makes hard cases.

Nutrition has been called kitchen science as one of the softer life sciences. It may look like a pure, white meringue with a hard crust, but squeeze it and you find a soft, gooey center. The more complicated the subject the greater the uncertainty, and the chemical complexity of food is compounded by the genetics and lifestyles of diners. And unlike testing a new drug, it is almost impossible for a study to strictly control the diet of its subjects long enough to reveal divergences in health. Consequently, we have a smorgasbord of slimming diets and food fads which are hard to prove or dismiss.

I favor Michael Pollan’s commonsense philosophy: “Eat food/ Not too much/ Mostly vegetables” (In Defense of Food). He applauds food that is not highly processed, farming practices with environmental integrity, and diets based on moderate food choices that reduce glycemic carbs. But it may not have appealed to Oscar Wilde who loved sweetmeats, and his father, Dr. Sir William Wilde, made his fortune in the sugar industry.

Next Post: Who knows about Fructose?

About Roger Gosden

British-born scientist specializing in human and animal reproduction & embryology. Academic career spanned from Cambridge and Edinburgh to McGill and Cornell's Weill Medical College in Manhattan where he was Professor & Research Director. Married to Lucinda Veeck Gosden, embryologist for the first successful IVF team in America, he retired early to Williamsburg, Virginia, to write and to recover from 'nature deficit disorder'
This entry was posted in Biomedical and tagged , , , , , , , , . Bookmark the permalink.